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Dearest gentle readers, Please join us in wishing Anissa a very happy 26th birthday! 🎂 🎉 Anissa, may your birthday be as enchanting as a ball in the ton! Wishing you a year ahead filled with love, laughter, and all the Bridgerton-worthy delights. 💎🌹✨ Yours truly, Chelsea’s Hope 📸 These photos are from Anissa’s Bridgerton-themed party over the weekend! Her mother, Jenifer, shared that, “she loved dressing up as Daphne. Anissa almost didn’t make it to her party due to seizure activity in the days leading up to her big celebration. Lafora is a cruel disease and robs our children of both small and big moments. I’m thankful Lafora didn’t win on her special day and that she experienced her “diamond of the season” moment surrounded by the love of family and friends. I am hopeful that this is the year we get a treatment and potentially a cure for Anissa and all the patients suffering from Lafora disease.” We hope for the same. Happy birthday, Anissa! 💜 #FightLafora #HappyBirthday #ChelseasHope #NotAStepBack @bridgertonnetflix #Bridgerton

5/6/2024, 4:41:11 PM

🆕 One-page research summary for families: ASO therapy!⁠ ⁠ ASO therapy has shown promising results in mouse models of Lafora disease, preventing Lafora Body formation and mitigating neuroinflammation. ⁠ ⁠ TITLE: Antisense oligonucleotide (ASO) therapy targeting Gys1 gene⁠ ⁠ AUTHORS: Saija Ahonen, Silvia Nitschke, Tamar R. Grossman, Holly Kordasiewicz, Peixiang Wang, Xiaochu Zhao, Dikran R. Guisso, Sahba Kasiri, Felix Nitschke and Berge A. Minassian⁠ ⁠ RESEARCH SIMPLIFIED BY: Maysoon Hussain⁠ ⁠ 🔗 Follow the link in our bio to read it!⁠ ⁠ You can also find the original publication linked on our website! ⁠ ⁠ #ChelseasHopeLaforaCure #LaforaDisease #LaforaDiseaseResearch #ChelseasHope #RareDisease #FightLafora #ASOTherapy #ION283 #Research #RareDiseaseResearch #CureLaforaDisease #NotAStepBack⁠ Media Description: The image has a photo of two hands holding a tablet with a PDF on it in front of a torso in a blue sweater, though the title is the only legible part of the PDF: Antisense oligonucleotide therapy targeting Gys1 gene. Text says 'Antisense oligonucleotide therapy targeting Gys1 gene ONE PAGE RESEARCH SUMMARY FOR FAMILIES.' There's a green graphic in the top left that says NEW! and the horizontal Chelsea's Hope Lafora Children Research Fund logo is in the bottom right-hand corner.

5/6/2024, 4:12:58 PM

. Viernes ya … despacito y con buena letra, pero sin dar un paso atrás y dejando huella … ¿habéis visto algún caracol rápido? ¿alguno andando marcha atrás? ¿alguno que no deje huella? Pues eso, parece que saben dónde van, con paciencia, sin recular, dejando tras de si un camino … así ando … intentándolo como ello … (aunque sin su paciencia 🙄 … aunque tampoco sabemos si la tienen 🤔) Feliz finde 🥰🤗😘💚 PD. Me encantan los caracoles … están riquísimos 🫣 … y son buenísimos si hablamos de nutrición, pero … no, me dediqué a rescatarlos y ponerlos en tierra segura … una cosa es comerlos, otra aplastarlos … corrían peligro 🥺 ‘𝐍𝐨 𝐢𝐦𝐩𝐨𝐫𝐭𝐚 𝐥𝐨 𝐥𝐞𝐧𝐭𝐨 𝐪𝐮𝐞 𝐯𝐚𝐲𝐚𝐬, 𝐬𝐢𝐞𝐦𝐩𝐫𝐞 𝐲 𝐜𝐮𝐚𝐧𝐝𝐨 𝐧𝐨 𝐭𝐞 𝐝𝐞𝐭𝐞𝐧𝐠𝐚𝐬.’ - Confucio - #snail #caracol #adelante #huellas #footprints #mark #trace #work #trabajo #objetivos #goals #dontgiveup #forward #notastepback #niunpasoatras #dreams #oneday #sueños #mylife #mumstyle #mumslife #forthem #healthylifestyle #vidasaludable #despacito #slow #keepgoing #friday #viernes #💚

4/26/2024, 8:09:06 PM

THANK YOU!! 💜⁠ ⁠ 41 of you gave $44,100 to our year-end fundraiser. WOW! 🎉👏⁠ ⁠ We are so grateful. And humbled!! Thank you for your generous support through a difficult couple of weeks.⁠ ⁠ We are glad to continue expanding and maintaining a strong, collaborative, and actionable research network in 2024.⁠ ⁠ Together, we #FightLafora.⁠ ⁠ #LaforaDisease #ChelseasHope #ChelseasHopeLaforaCure #PatientCommunity #UnitedAgainstLafora #UnittiContraLaLafora #NotAStepBack

1/5/2024, 9:05:10 PM

Hello 2024✨ #notastepback #onlygoodvibes

1/1/2024, 7:00:28 PM

Yo no le creo a un dios de palo que no escucha a sus hijos yo le creo al Dios que creó todo lo que mis ojos pueden ver y aún lo que no pueden visualizar. Mi apóstol me dijo primero viene el peso en tus hombros, luego viene la visión. El peso lo siento, la visión ya fue dada y el profeta habló UN PASO ATRÁS NÓ NÓ NÓ (Not a step back) La respuesta está en la palabra que te di. Gracias @johnnyfelizoficial por ser de bendición a mi casa 🙏🏾 #unpasoatrasno #notastepback #revisalapalabraquetedi #newstepchurc #NSC👣 #CFI⛲️

12/19/2023, 1:46:49 AM

#dontmissthemoment #notastepback 😻😻😻

11/7/2023, 11:24:08 AM

Lafora by Disney Pixar 😊💜 IA •Ni un paso atrás• #lafora #laforadisease #raredisease #pixar #disney #notastepback #disneyinclusion #inclusivedisney #aevel #ia

10/22/2023, 1:32:41 AM

“ Dovrei lavorare meno e dormire di più ma è l’ambizione a provocarmi l’insonnia… “ . . . #notastepback #insomnia #target 👀⏳😏

10/18/2023, 4:03:24 PM

That f*cking sense of freedom! #firstlesson #polefitness #selfstudying #strenght #mind #notastepback

10/15/2023, 8:20:31 PM

It's so easy to fall... . Into the negative self talk. . Off track. . Out of routine. . It's hard not to beat yourself up when things like this happen. . But you can choose. . To stay in the negative. . To stay off track. . To stay in a comfortable routine. . OR . You can choose. . To counter the negative self-talk with a positive thought. . To get back on track with the next choice you make. . To push yourself outside your comfort zone and create a routine that moves you forward. . You can acknowledge those icky feelings you have, let them know that you hear and feel them, but then it's time to move on. . And the best way to dig yourself out of them is with action. . Action that serves you and moves you forward. . Take a hot shower and paint your toes. . Go for a walk and breathe in some fresh air. . Show yourself some kindness by cooking yourself a nourishing meal. . Write out 5 things you like about yourself. . When you fall, it's not losing progress. It's not taking a step back. . It's a reminder that you are human and that you have a choice. . . . Today, I am choosing kindness towards myself because I am feeling the negative creep in. . For me, that looks like journaling, lots of water, and paying attention to what I do like about myself. . . . Where are you at today? What are you choosing? . . . Let me know in the comments, or feel free to send me a DM. 🤍✨️ . . . . . . #youcanchoose #thechoiceswemake #notastepback #actioncreateschange #nourisheveryday #nourisheverydaywithkristen

10/13/2023, 7:36:26 PM

At this point, I think it's the smartest move you can make!!

10/3/2023, 5:50:05 PM

#copenhagenpride is one of the best day in the year … that’s really an event for everyone… when today I saw @mette - Danish PM - just in the middle of the crowd shaking hands I could not avoid and comparing to the Italian PM. Then I remembered that in this country I’m #married but not in my own. #maturedemocracy #inclusivity #diversity #loveislove🌈 #equality #notastepback

8/19/2023, 11:32:49 PM

Now I will take full lungs of air and take a course only forward and not a step back. #notastepback #fyp #forward #✌🏻 Давно не было таких обычных селфи в ленте 😇

7/13/2023, 11:32:19 PM

It's not about ego,But once I feel ignored or unwanted,I make distance by myself No matter how close we are... #notastepback #movingahead #enjoyeverymoment❤️

4/10/2023, 4:32:21 PM

Not a step back❌ . . . #barnaul #barnaul22 #barnaulinsta #barnaulrussia #brn #girlswithtattoos #girl #black #blackandwhite #notastepback #first #барнаул #барнаул22 #барнаул22rus #барнаулонлайн #брн #тольковперед #первая

3/22/2023, 8:13:33 AM

Ni un paso atrás #8m #mujer #derechos #feminismo #woman #rights #notastepback

3/8/2023, 3:20:33 PM

#notastepback

1/23/2023, 8:40:17 AM

BE LIKE DRUGS AND LET THEM DIE FOR YOU.💫 #notastepback #livinglifetothefullest #enjoyingeverymoemnt

9/4/2022, 6:54:44 PM

Not a step backwards 🎯 Сегодня был очередной крутой праздник бега для любителей и профессионалов. Сегодня все отбегали свою дистанцию несмотря на жару. Всегда готовы на любые условия, главное дайте нам побегать. В середине августа решилась бежать 5км на скорость, вызов себе и выход из зоны комфорта, так как я runner на длинные дистанции. Подготовка на 5км и 21,1км разная, фокус разный, специфика разная. В итоге прибежала за 24:07 со средним темпом 4:40🏅 Оставшиеся 1км бежала и повторяла себе «терпи, лошадка, терпи». #notastepback 🏆 Заняла 4 место в своей возрастной категории и 9 в абсолюте. Можете поверить? Когда только начинала была в 100-ке, где-то 900-ая. Свой первый забег «Герой Локации - Атакент» прибежала, дошла за 30 мин (4км). После которого решила быть в команде с тренером. Кто-то увидит прогресс, кто-то упорный труд, кто-то дисциплину, кто-то непонятные цифры. И каждый будет прав. Но ценнейшим для меня являются суппорт, вера и вклад моего тренера. Который 24/7 работает, чтобы сделать из нас чемпионов своей жизни. Спасибо тебе за лучшую версию меня 🥇 Твой ученик Айгерим Бекеле получил feedback, фокус есть, цели стали яснее. @aitimov.madi Мы на верном пути! Таков путь! Путь марафонца! @almaty_night_run.kz #путьмарафонца #notastepback #runhappy #marathoner #youngrunner #runningcommunity #runninglife #runninggirl #runningmom

8/28/2022, 5:12:39 PM

Тату надпись – НИ ШАГУ НАЗАД – ТОЛЬКО ВПЕРЕД – на коленях у парня https://tatufoto.com/category/ulichnaya-tatuirovka/ #Нишагуназад, #тольковперед, #татунадпись, #татутекст, #татумотивация, #татусосмыслом, #татунаноге, #татунаколене, #мужскаятату, #пареньстату, #Notastepback, #onlyforward, #tattooinscription, #tattootext, #tattoomotivation, #tattoowithmeaning, #tattooontheleg, #tattooontheknee, #maletattoo, #guywithatattoo,

8/21/2022, 3:03:29 PM

La Orden 227 fue un comunicado promulgado el 28 de julio de 1942 por Iósif Stalin en su calidad de Comisario de Defensa del Pueblo. Es conocida sobre todo por la frase «¡Ni un paso atrás!», que se convertiría en el lema principal de lucha de la resistencia antifascista soviética​ durante la Gran Guerra Patria. #order227 #notastepback #thesovietunion #sovietarmy #sovietunion #urss #rusia #russia #worldwar2history #theredarmy #redarmy #ejercitorojo #elejercitorojo #losifstalin #iosifstalin #stalin #modernwarfare #niunpasoatrás

8/18/2022, 2:09:34 PM

Only forward and not a step back Non Ame #NonAme #notastepback #mystagemyrules #myband #mychannel #hardandheavy

7/26/2022, 9:40:14 PM

Откровение трёх В, в этом мире, возможно, всё. ©Денис Погодицкий The revelation of three in,In this world, maybe, everything. ©Deni Pogoditsky How do you like my video🎥? ✍️Write your opinion in the comments📄. Как вам моё видео🎥? ✍️Пишите своё мнение в комментариях📄. Музыка N O M I N A L - EVERYDAY ANYONE (DATURA Remix) Music N O M I N A L - EVERYDAY ANYONE (DATURA Remix) Выражаю благодарность своему другу, @brumel_jr за редактирование текста. Если вам понравился пост, то буду очень благодарен если вы мне за мои старания поставите лайк👍, коммент📣 и сохранение, что бы больше людей увидела мой интересный пост и это даст мне больше мотивации,дальше делать для вас интересные посты, а также по любым вопросам взаимного сотрудничества, пишите в директ. Подпишись на @den_pogoditsky😁 Subscribe to @den_pogoditsky #motivationeveryday💪 #insportstyle #goforward👣 #nevergiveuphk #nevergiveup💪🏿 #dontgiveuponyourdreams❤️ #notastepback #hardworkers💪 #thepathtosuccess #gotosuccess📈💸 #den_pogoditsky  #roadtothedreammotivation

6/20/2022, 10:16:02 AM

A must listen…very well said #amberheard #notastepback #stepforward

6/3/2022, 2:38:42 AM

In the end , they'll judge me Anyway ,so whatever. #instagood #lifequotes #lifelessons #goals❤️ #alwaysastepahead #notastepback #

4/15/2022, 7:47:45 PM

😂😂😂 @karmoruu #hilarious #notastepback

2/19/2022, 6:48:46 PM

#EVERYONE IS A #GANGSTER UNTIL ~THE REAL~ #GANGSTER ARRIVES. #notastepback

2/16/2022, 2:11:50 PM

#мамаевкурган #мамаев_курган #mamaevkurgan #mamaev_kurgan #mamaevhill #нишагуназад #notastepback #ни_шагу_назад #стоятьнасмерть #стоять_насмерть #родинаматьзовет #родина_мать_зовет #родинаматьзовёт #родина_мать_зовёт #родинамать #родина_мать #motherlandcalls #скульптура #sculpture #скульптуры #sculptures #волгоград #volgograd #volgograd_34 #регион34 #россия #russia

2/9/2022, 1:36:57 PM

Go forward to your dream🧩 #dream #Notastepback #sunset #해질녘

1/28/2022, 4:59:37 PM

_ Not a step back _ Загляни в сторис 😉 @nastyusha_mouse #notastepback #мотивашка #тольковперед #зима2022 #фрилансеры #чита75 #надому #обучение #обучениефрилансу #удаленнаяработа #удаленка #обработкафото #bts

1/24/2022, 6:40:19 AM

Inspiration tattoo! #tattooonhand #tattoophrases #frases #tatuajes #нишагуназад #notastepback #тату #татунаруке #tatuforever #tatupodolsk #татуподольск

1/22/2022, 2:13:47 PM

People ask me all the time “You are always smiling, how do you do it?” My answer always is: “I chose to be grateful every day for the blessings that are given to me” Don’t confuse happiness with lack of stress, don’t confuse a smile with not being afraid… This semester has being tough but the month of November of 2021 has been a month with a lot of exciting great news…but very frightening to say the least. I choose to attack every challenge in front of me with a smile on my face and determination. I know that whatever onstacle is on my path I can overcome it and grow into a much better husband, father, son, coach, mentor and friend. Proverbs 3:5-6 … “he will make your paths straight.” • • • #proberbs #vamos #icandothis #greatnews #challengeaccepted #notastepback #paraatrasniparacogerimpulso #yosoytico #tico #faith

11/18/2021, 8:23:40 PM

I may not know your EXACT situation…but I do know what you’re going through and always glad to help! #NotReadyYet #NeverGiveUp #ItsAllinHowYouRespond #NotAStepBack but a #StepUp!!! #useyourgiftsinTHISmoment

11/8/2021, 6:43:30 PM

Nivel desbloqueado! #nevergiveup #stepbystep #notastepback

11/3/2021, 3:56:20 AM

#настроение , как у осеннего листочка: оторваться. #осень #🍁 #🍂 #пустьлюбимыебудутрядом #скучаю #люблю❤️ #autumn #moodoftheday #potd📷 #lovemybabies #takecareofyourself #beyourself #tajikwoman #newlife #newdreams #newgoals #onlyforward #dreamscometrue #notastepback #bestrong #everythingisinyourhands #dontbackdown #nomatterhowharditwas

10/30/2021, 8:07:59 PM

Tiempo de reflexión y ordenamiento. #nevergiveup #reflection #planning #notastepback

10/16/2021, 8:13:47 PM

Bloody T-shirt just right for this sport🔥🔥 T-shirt "PsychoMMAniack". -Weight 210g -Made od high-quality thick cotton #octagonfightwear #octagonireland #welcometoireland #irishmma🇮🇪 #dubliners #kildareireland #fightislife #naaskickboxingandfitness #notastepback #martialartsireland #fightstyle #bloodsports

9/7/2021, 4:05:47 PM

Вся жизнь-эспрессо,а ты в ней буква «К»🙃 #notastepback

9/1/2021, 8:21:58 PM

Самарская набережная. #ural_travel #cat #gotovolga #notastepback #samara

8/13/2021, 10:39:23 AM

🇷🇺 ~ «Будем стоять насмерть!» (июнь - август 1944) Автор: Эммануил Евзерихин Место съемки: Белорусская ССР О фотографии: 2-й Белорусский фронт, 1944 год, на артиллерийской позиции. 🇬🇧 ~ "We will stand to the death!" (June - August 1944) Photographer: Emmanuel Evzerikhin Picture location: Belarusian SSR About the photo: the 2nd Belorussian Front, 1944, at an artillery position. #вов #ВеликаяОтечественнаявойна #Бессмертныйполк #ветеран #ветераны #война #эммануилевзерихин #евзерихин #беларусь #Белорусскаясср #нишагуназад #WW2 #easternfront #lmmortalRegiment #veteran #veterans #war #emmanuelevzerihin #evzerikhin #belarus #belarusianssr #1944 #notastepback

8/10/2021, 8:05:26 PM

Чашечка для огромного пельменя=))) #travel #cat #ural_travel #gotovolga #notastepback #kazan

8/10/2021, 5:50:45 PM

Казань... #ural_travel #cat #gotovolga #notastepback #kazan #kulsharif

8/10/2021, 2:41:29 PM

Спустя 2 дня пляжей и рыбалки, сгоревшие с ног до головы мы в Казани=) #travel #ural_travel #cat #gotovolga #notastepback #kazan

8/10/2021, 2:15:20 PM

Сегодня ночуем так) #travel #ural_travel #cat #gotovolga #notastepback

8/7/2021, 5:59:09 PM

Волга+Кама. @vini_ekt #travel #ural_travel #cat #gotovolga #notastepback

8/7/2021, 4:29:23 PM

Ещё один театр оперы и балета) #travel #cat #ural_travel #gotovolga #notastepback #izhevsk

8/4/2021, 9:06:50 PM

Иж кар... #ural_travel #gotovolga #notastepback #travel #cat #izhevsk

8/4/2021, 5:10:49 PM

Пермский театр оперы и балета. #ural_travel #cat #gotovolga #notastepback

8/4/2021, 11:30:30 AM

Не за горами. @vini_ekt #travel #ural_travel #gotovolga #notastepback

8/4/2021, 10:46:54 AM

On the road. #ural_travel #gotovolga #notastepback #travel

8/3/2021, 5:59:57 PM

🇷🇺 ~ 28 июля 1942 года народный комиссар обороны СССР Иосиф Сталин подписал приказ №227, который запрещал отступление Красной армии без советующего распоряжения. В народе этот документ получил название «Ни шагу назад». 🇬🇧 ~ On July 28, 1942, the People's Commissar of Defense of the USSR, Joseph Stalin, signed order No. 227, which prohibited the retreat of the Red Army without a order. This document was popularly called "Not a step back". #вов #ВеликаяОтечественнаявойна #Бессмертныйполк #ветеран #ветераны #война #нишагуназад #WW2 #easternfront #lmmortalRegiment #veteran #veterans #war #notastepback

7/28/2021, 8:06:12 PM

𝗜𝗣𝗜𝗡𝗔𝗚-𝗨𝗧𝗢𝗦 𝗡𝗜 𝗝𝗢𝗦𝗘𝗣𝗛 𝗦𝗧𝗔𝗟𝗜𝗡 𝗔𝗡𝗚 "𝗡𝗢𝗧 𝗔 𝗦𝗧𝗘𝗣 𝗕𝗔𝗖𝗞!" 𝗢𝗥𝗗𝗘𝗥 July 28, 1942 "Not one step back!" Ito ang naging islogan ng kautusang ipinroklama ng Premier ng Soviet Union at People's Commissar for Defense na si Joseph Stalin sa araw na ito noong 1942. Ang Order no. 227, na isinabatas ni Stalin, ay bilang tugon ng pamahalaang Soviet sa malakihang desersyon ng ilang mga sundalong Soviet, mula nang salakayin ng Nazi Germany ang Soviet Union noong Hunyo 1941, at layunin ng nasabing batas na mapanatili ang moral at disiplina ng Red Army sa harap ng pasistang kalaban. Ipinatupad ang Order no. 227 sa lahat ng mga batalyon, mga iskwadron, at mga punong himpilan ng Red Army. Ayon sa nasabing batas, bawat regimental front ng Red Army ay magtatatag ng isa o tatlong penal battalion, kung saan ang mga mahuhuling sundalong Soviet na umaatras ay ilalagay sa penal battalion at idedestino sa mas mapanganib na bahagi ng labanan, bilang parusa sa kanilang walang permisong pag-atras. Ipinagbabawal ng nasabing batas ang walang permisong pag-atras ng kahit sinong mga heneral, kundi ay isasakdal ang mga pasaway na mga komandante o heneral sa hukumang militar. Ipinag-utos rin sa Order no. 227 ang pagtatalaga ng "blocking detachment" kung saan isang linya ng mga sundalong Soviet ang ilalagay sa likuran ng mga umaabanteng yunit ng Red Army upang barilin agad ang sinumang mahuhuling nagpapakita ng karuwagan sa harap ng labanan. Naging popular ang blocking detachment na ito sa labanan sa Stalingrad, na nagsimula noong Agosto 1942. Pero dahil sa notoryus na reputasyon nito at nakitang hindi ito praktikal na paraan para maiwasan ang karuwagan sa mga sundalo, tahimik nang inalis ang blocking detachment noong Oktubre 1942 at binuwag sa bisa ng Order no. 349 na nilagdaan ni Stalin noong Oktubre 1944. (...) #NgayongArawSaKasaysayan #NotAStepBack #OrderNo227 #JosephStalin #WorldHistory #SocSciclopedia

7/28/2021, 4:28:43 PM

Not a step back 🙂 #notastepback #likeforlikes

4/20/2021, 11:31:56 PM